An Autoregulatory Mechanism Governing Mucociliary Transport Is Sensitive to Mucus Load
نویسندگان
چکیده
منابع مشابه
Nasal mucociliary transport is impaired at altitude.
There have been a number of anecdotal reports of rhinitis and nasal obstruction occurring at altitude. To quantify these reports, we investigated nasal obstruction and mucociliary transport in a group of healthy volunteers trekking to Mount Everest Base Camp, Nepal, altitude 5,300 m. Nasal obstruction was estimated by subjective scoring and mucociliary transport was determined by the saccharin ...
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The development of pathologic mucus, which is not readily cleared from the airways, is an important contributor to the morbidity and mortality associated with asthma. It is not clear how the major airway mucins MUC5AC and MUC5B are organized within the mucus gel or how this gel contributes to airway obstruction in asthma. Here, we demonstrated that mucus plugs from individuals with fatal asthma...
متن کاملMethods for studying mucociliary transport.
UNLABELLED Mucociliary transport dysfunctions can impair the quality of life of patients suffering from chronic rhinossinusitis and lead to severe consequences such as alterations in respiratory physiology or even death as in cases of cystic fibrosis and primary ciliary dyskinesia. Therefore, it is crucial to understand the physiology of the mucociliary apparatus and how its components (cilia, ...
متن کاملMucociliary transport in ICU patients.
OBJECTIVES The objectives of this study were to determine the bronchial mucus transport velocities in ventilated ICU patients and to study the possible role of impaired mucus transport in the development of retention of secretion and pneumonia. DESIGN The patients were studied prospectively in a convenience sample trial. SETTING The study took place at a university hospital. PATIENTS Thir...
متن کاملBronchial Mucus Transport
Effective clearance of inhaled particles requires mucus production and continuous mucus transport from the lower airways to the oropharynx. Mucus production takes place mainly in the peripheral airways. Mucus transport is achieved by the action of the ciliated cells that cover the inner surface of the airways (mucociliary transport) and by expiratory airflow. The capacity for mucociliary transp...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2014
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2013-0499ma